article · Kidney International Reports
Introduction: Donation nephrectomy reduces the renal parenchyma and therefore the glomerular filtration rate.It is relevant to identify long-term clinical and biochemical outcomes.Methods: The aim of this study was to evaluate the long-term metabolic and renal outcomes in a retrospective cohort.We used the Electronical Medical Record at Instituto Nacional de Ciencias Mdicas y Nutricin Salvador Zubirn.We included 303 living kidney donors over 18 years of age who donated between the years 2000 and 2024.Patients were classified into three groups according to the time since donation: <10 years (n=97), 10 -20 years (n=121), and >20 years (n=85).Results: The mean age of our cohort was 53.9 13.1 years, with an average BMI of 26.97 4.57 kg/m 2 .The mean absolute weight gain was 4.13 8.64 kg, with a mean relative weight increase of 6.41% 13.78%.It is relevant that 24.1% (n73) of the donors met the definition of obesity, with a BMI 30 kg/m 2 .The current mean estimated Glomerular Filtration Rate (eGFR) in donors was 76.84 16.86 ml/min/1.73m2 and a mean urine albumin to creatinine ratio (UACR) of 21.85 66.71 mg/g.A trend to increase UACR was identified in the group of patients with a longer time since donation, which was statistically significant (p=0.0045).Regarding comorbidities, the prevalence of hypertension showed a significant increase with the time since donation (p < 0.001), reaching 34.1% in the group with more than 20 years post-donation.Type 2 diabetes and albuminuria showed a trend toward higher prevalence in the groups with longer time since donation but did not reach statistical significance (p = 0.092 and p = 0.064, respectively).No significant differences were observed in the prevalence of dyslipidemia, cerebrovascular events, acute myocardial infarction, or peripheral arterial disease. Conclusion:Donors may be at risk of developing hypertension, components of metabolic syndrome and elevated urinary albumin excretion, along with an anticipated mild decline in eGFR.This highlights the importance of continuous monitoring of kidney donors in our country to identify potential risk factors for worsening chronic kidney disease.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.
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DOI: 10.1016/j.ekir.2026.105519
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