Value of N-terminal proBNP in patients with mitral stenosis

Abstract

Introduction: Mitral valve stenosis (MS) is an important valvular disorder in developing countries. N-terminal part of pro B type natriuretic peptide (NT-proBNP) has been used as a diagnostic and/or prognostic biomarker for clinical outcomes in some cardiac disorders.Aim: To show the association between NT-proBNP levels and hemodynamic variables in mitral stenosis patients.Patients and methods: Forty six patients with severe MS and sinus heart rhythm and twenty five healthy individuals as a control group were enrolled and NT-proBNP levels were assessed in them.Results: Mitral stenosis patients have higher levels of NT-proBNP in comparison of the control subjects. The severity of dyspnea was correlated with NT-proBNP levels. Also, left atrial size and pulmonary arterial pressure were significantly related to NT-proBNP levels. Conclusion: NT-proBNP is increased in MS patients and is associated with clinical and haemodynamic variables. Therefore, NT-proBNP may be used as a complementary variable with the clinical and echocardiographic evaluations in MS patients.Keywords: Mitral stenosis, NT- proBNP.