review · Journal of Clinical Oncology
Vaccination aims to reduce the severity of infections and prevent them wherever possible, making the management of vaccine status a crucial part of cancer care. Clinical care should include recording a patient's immunisation history at their initial visit, administering recommended vaccines promptly, and delivering suitable revaccination following treatments such as hematopoietic stem-cell transplantation, chimeric antigen receptor T-cell therapy, or B-cell-depleting therapy. Because underlying immune suppression and specific cancer therapies influence vaccine response, strategies for these individuals often differ from guidance issued for the general healthy adult population. Successful delivery relies on active coordination across multidisciplinary clinical teams, including primary care practitioners, pharmacists, and nurses. Furthermore, vaccinating household members provides an additional layer of protection for individuals undergoing cancer treatment.
Cancer treatments often weaken the immune system, leaving patients vulnerable to severe and preventable infections. Adapting vaccine schedules to individual cancer therapies ensures protection is delivered safely and effectively. Involving household contacts and coordinating closely across primary care, pharmacy, and oncology teams creates a protective environment that reduces infection risks during critical stages of cancer management.
The guidance offers ready-to-use protocols that can be directly integrated by healthcare providers, hospital networks, and developers of clinical decision-support software. While the abstract describes clinical practice recommendations rather than a discrete technology or product, the pathways can be applied immediately within digital health platforms and electronic health record systems to automate revaccination tracking for oncology patients.
AI-generated from the published abstract. Always read the original work before citing.
The goal of vaccination is to limit the severity of infection and prevent infection where feasible. Optimizing vaccination status should be considered a key element in the care of patients with cancer. This approach includes the documentation of vaccination status at the time of the first patient visit; timely provision of recommended vaccines; and appropriate revaccination after hematopoietic stem-cell transplantation, chimeric antigen receptor T-cell therapy, or B-cell-depleting therapy. Active interaction and coordination among healthcare providers, including primary care practitioners, pharmacists, and nursing team members, are needed. Vaccination of household contacts will enhance protection for patients with cancer. Some vaccination and revaccination plans for patients with cancer may be affected by the underlying immune status and the anticancer therapy received. As a result, vaccine strategies may differ from the vaccine recommendations for the general healthy adult population vaccine.Additional information is available at www.asco.org/supportive-care-guidelines.
This page summarises published work. The authoritative version sits with the publisher.
DOI: 10.1200/jco.24.00032
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