article · Open Forum Infectious Diseases

Utility of Cerebrospinal Fluid Unstimulated Interferon-Gamma (IRISA-TB) as a Same-Day Test for Tuberculous Meningitis in a Tuberculosis-Endemic, Resource-Poor Setting

Philippa Randall
Junior Mutsvangwa
Lindsay Wilson
Shungu Munyati
Beauty Makamure
Keertan Dheda
Marriott Nliwasa
Edson Makambwa
Omar K. Siddiqi
Elizabeth L. Corbett
Richard Meldau
Ali Esmail

20242 citationsOpen accessUniversity of Malawi

Abstract

As a same-day rule-in test, IRISA-TB had significantly better sensitivity than Xpert Ultra in a TB/HIV-endemic setting. An immunodiagnostic approach to TBM is promising, and further studies are warranted.

Research topics

Infectious Diseases and Tuberculosis
Tuberculosis Research and Epidemiology
Mycobacterium research and diagnosis

Sustainable Development Goals

Good Health and Well-being

Read the original research

This page summarises published work. The authoritative version sits with the publisher.

View on publisher site Record on OpenAlex

DOI: 10.1093/ofid/ofae496

Is something wrong with this record? Report it or request removal.

Discussion

Discuss this research

Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.

No discussion yet. Open the first thread.

New to MARATTO™? Create a free account.