URINARY C PEPTIDE/ CREATININE RATIO AND ITS RELATION TO INSULIN RESISTANCE AND VASCULAR COMPLICATIONS IN TYPE 2 DIABETES

Abstract

INTRODUCTION:Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance (IR) which leads overtime to hyperglycemia and progressive beta cell dysfunction. IR is a potent risk factor for vascular complications of diabetes including macro and microvascular complications, which contribute significantly to morbidity and mortality. Urinary c peptide, a byproduct of insulin secretion, serves as a reliable biomarker for beta cell function due to its stability in urine and it is easy to collect. When normalized to creatine levels, the urinary c peptide creatinine ratio (UCPCR) provides a simple, noninvasive measure of endogenous insulin secretion. Close correlations between serum C-peptide, and UCPCR have been shown. And since, high serum C-peptide concentration is a strong indicator of metabolic syndrome and IR, this suggests that UCPCR could be a promising marker for assessing IR.AIM OF THE WORK:The aim of the present study was to assess urinary c peptide /creatinine ratio in patients with T2DM and its relation to insulin resistance and vascular complications.