article · PLoS Biology
A novel, non-discriminatory classification system for monkeypox virus diversity has been proposed. This system, developed in collaboration with the World Health Organisation, names three distinct clades: I, IIa, and IIb, ordered by their detection. Within clade IIb, which is identified as the cause of the current global outbreak, several specific lineages have been identified, including A.1, A.2, A.1.1, and B.1. The primary purpose of this detailed classification is to support and enhance real-time genomic surveillance efforts for the monkeypox virus.
This research provides a standardised and non-stigmatising way to classify monkeypox virus strains. This is crucial for public health, as it allows scientists and health organisations to accurately track the virus's spread and evolution globally, informing effective response strategies and preventing miscommunication or discrimination.
This classification system is an applied research output directly supporting public health operations. It provides a standardised framework for real-time genomic surveillance, which is immediately usable by public health agencies, diagnostic laboratories, and research institutions involved in tracking infectious diseases. It enhances the ability to monitor outbreaks and understand viral evolution, serving as a foundational tool for epidemiological and diagnostic work.
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We propose a novel, non-discriminatory classification of monkeypox virus diversity. Together with the World Health Organization, we named three clades (I, IIa and IIb) in order of detection. Within IIb, the cause of the current global outbreak, we identified multiple lineages (A.1, A.2, A.1.1 and B.1) to support real-time genomic surveillance.
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DOI: 10.1371/journal.pbio.3001769
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