article · Phosphorus, sulfur, and silicon and the related elements
A green and efficient approach was developed for the synthesis of twenty-three α-aminophosphonate derivatives (<b>4a</b>-<b>4v</b>) <i>via</i> the Kabachnik–Fields reaction, using acetylsalicylic acid as a novel eco-friendly Brønsted acid catalyst under ultrasound irradiation and solvent-free conditions. The target compounds were obtained in moderate to excellent yields (43 - 91%) and were structurally characterized by FTIR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, and single-crystal X-ray diffraction analysis. Notably, the crystal structure of compound <b>4c</b> was elucidated by X-ray diffraction, providing detailed molecular and supramolecular insights. The antioxidant activity of the synthesized compounds was evaluated through four <i>in vitro</i> assays (DPPH, ABTS, FRAP, and phenanthroline), with compounds <b>4a</b>, <b>4c</b>, <b>4d</b>, and <b>4k</b> demonstrating significant potency. Additionally, antifungal activity was assessed against <i>Fusarium oxysporum f. sp. lycopersici</i>, with compound <b>4t</b> exhibiting the highest inhibitory effect.
This page summarises published work. The authoritative version sits with the publisher.
DOI: 10.1080/10426507.2025.2584184
Is something wrong with this record? Report it or request removal.
Discussion
Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.
No discussion yet. Open the first thread.
New to MARATTO™? Create a free account.
