review · South African Journal of Botany
Lavandula dentata L., a member of the Lamiaceae family, is frequently used in traditional medicine to treat conditions such as diabetes, inflammation, and microbial infections. Chemical profiling shows that the plant is rich in diverse phytochemicals, particularly terpenoids, flavonoids, and phenolic acids. Essential oils and organic extracts from the species display multiple biological properties, including antibacterial, antifungal, antioxidant, anti-diabetic, anticancer, and anti-inflammatory actions. Even at low concentrations, these preparations specifically inhibit enzymes, cellular receptors, proteins, and signalling pathways linked to the development of these disorders. These pharmacological actions support the traditional therapeutic use of the plant. However, further research is required to evaluate pharmacokinetic profiles and conduct toxicological testing to identify any potential toxicity prior to conducting future clinical trials.
Documenting the chemical constituents and mechanisms of medicinal plants provides a scientific foundation for understanding traditional therapies. Identifying how Lavandula dentata extracts target disease pathways helps bridge traditional botanical medicine and modern therapeutic research, while underscoring the necessity of systematic toxicity testing before plant-based preparations can be safely advanced toward clinical use.
The findings point toward early-stage therapeutic applications in developing treatments for infections, diabetes, or inflammatory disorders. Pharmaceutical and natural product developers could explore these bioactive extracts as candidate materials. However, the research is at an early scientific stage, and real-world commercial translation remains distant until comprehensive pharmacokinetic profiling and toxicological evaluations are completed to establish safety.
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• The traditional properties of Lavandula dentata was reported. • Biological activities of Lavandula dentata were reviewed with earlier papers from different databases. • Chemical constituents (mostly terpenoids and phenolic compounds) of Lavandula dentata were reported. • This review will be a scientific baseline for further studies regarding Lavandula dentata . Lavandula dentata L. is a medicinal plant belonging to the Lamiaceae family, frequently used in traditional medicine to treat various pathologies such as diabetes, inflammation, microbial infections, and other disordors. The present work aims to explore this medicinal plant by highlighting its ethno-medicinal uses, its phytochemical characteristics, as well as its pharmacological and industrial properties on a global scale. Thus, in this review, the highlighted properties are reported to explore possible therapeutic pathways of L. dentata . As reported, this medicinal species is rich in different phytochemicals belonging to several chemical families, including phenolic acids, flavonoids, and terpenoids. Indeed, L. dentata chemical compounds are characterized by several promising biological and pharmacological properties. These bioactivities include antibacterial, antifungal, antioxidant, anti-diabetic, anticancer, anti-inflammatory effects, etc. In fact, and even at low concentrations, L. dentata essential oils (EOs) and organic extracts specifically inhibit enzymes, membrane or intracellular receptors, proteins or signaling pathways involved in the genesis of these pathologies. The findings of this work revealed that the pharmacological activities of L. dentata confirm the importance, the diversified use, and the effectiveness of this plant in the traditional remedies of many diseases. Nevertheless, pharmacokinetic validation and toxicological examinations are required to detect any possible toxicity for future clinical trials.
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DOI: 10.1016/j.sajb.2023.01.023
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