Toxicological evaluation of leaf extract of Terminalia chebula extract on wistar rats biochemical parameters

Abstract

Terminalia chebula is widely utilized in South Asia, ranging from India to Africa. It is frequently utilized in the treatment of many illnesses. The purpose of this study is to determine the toxicity of Terminalia chebula on the lungs, blood, and heart of wistar rats. The first group received distilled water (10 ml/kg), while the second, third, and fourth groups received Terminalia Chebula 200, 400, and 800 mg/kg, respectively. Animals were kept in conventional cages and provided oral access to extract, water, and food for 28 days before being weighed and slaughtered. Blood was drawn for hematological and chemopathological testing. The lungs and brain were also removed for histopathological examination. There was a substantial (P<0.05) drop in RBC, HGB, and MCV, but no change in neutrophils, basophils, eosinophils, or platelets. When compared to the control, Terminalia chebula induced a small but not statistically significant (p<0.05) increase in the size of the heart and lungs at all doses. When compared to the control, there was no significant (p<0.05) change in triglyceride or HDL levels, however there was a significant (p<0.05) decrease in LDL levels. At all doses, there were minor alterations in histological characteristics. The study's findings indicated that at normal doses, the plant may have no adverse compromise on several organs.