article · Bioorganic Chemistry

Towards the discovery of potent epigenetic modulators: Design, synthesis, biological evaluation, and SAR investigation of novel indole-based derivatives targeting HDAC1 and HDAC6

Sarah Shawky
Sameh H. Soror
Maiy Y. Jaballah
Hesham Haffez
Tarek Erfan Ahmed
Nermin Samir
Aya Sobhy
Maged Henary
Deena S. Lasheen

2026Helwan University

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Research topics

Histone Deacetylase Inhibitors Research
Protein Degradation and Inhibitors
Epigenetics and DNA Methylation

Sustainable Development Goals

3Good Health and Well-being

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DOI: 10.1016/j.bioorg.2026.109772

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