Therapeutic Strategies for Asthma Concurrently Occurred with Obesity.

Abstract

One of major global problems is obesity, which can lead to inflammation in the form of hyperlipidemia, lung abnormalities, and asthma. An abnormal buildup of fat that poses a risk to health is obesity. The incidences of obesity in adults and children are still rising. Obesity is a disease that has a significant impact on asthma in both adults and children. Excessive obesity-induced systemic inflammation has been linked to the physiopathology of a number of diseases and has been suggested as a potential mechanism for the onset of asthma in obese people. Obesity-related inflammation is thought to be caused by M1 macrophage infiltration of adipose tissue and elevated expression of several mediators that intensify and spread inflammation. Adipose tissue serves as a significant reservoir for adipokines, including the pro-inflammatory leptin that is overpro8duced in obesity and the anti-inflammatory adiponectin that is synthesized at a reduced rate. Pro-inflammatory cytokines like IL-1β, TNFα, and NF-KB are synthesized during the inflammatory process and play a role in the pathogenesis of asthma. The objective of this review is to evaluate the role of medication in treatment obesity and its influence in improve asthma.