review · Pharmaceuticals
Conventional disease treatments such as chemotherapy and radiation therapy face growing limitations and adverse side effects, driving demand for natural therapeutic alternatives. Marine probiotics, which are beneficial microorganisms found in ocean environments, produce a wide variety of bioactive primary and secondary metabolites with potential health benefits. Among these organisms, Pseudoalteromonas species represent a widespread group of rod-shaped, flagellated, gram-negative bacteria that do not form spores. These marine bacteria demonstrate notable therapeutic capabilities, particularly anticancer and antibacterial activities. Understanding the biological mechanisms, production techniques, and therapeutic properties of marine probiotics provides a foundation for developing novel natural treatments. Examining the specific effects of Pseudoalteromonas species highlights opportunities and future directions for utilising marine-derived bioactive compounds to combat bacterial infections and malignant diseases.
Existing medical interventions like chemotherapeutic drugs and radiation can cause severe adverse effects and face treatment limitations. Exploring natural compounds from ocean bacteria introduces alternative ways to tackle cancer and microbial infections. By examining the therapeutic properties of marine probiotics such as Pseudoalteromonas, researchers and developers gain clearer pathways toward identifying less harmful, biologically derived medical treatments.
This work points towards potential applications in pharmaceutical development for novel anticancer and antibacterial agents derived from marine natural products. Intended users would include biopharmaceutical researchers, drug developers, and industrial biotechnologists focused on therapeutic biomanufacturing. Because the evidence is presented as a survey of existing studies and production concepts rather than a newly tested clinical formulation, the underlying technology sits at an early, exploratory stage of research and development.
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Due to the increasing limitations and negative impacts of the current options for preventing and managing diseases, including chemotherapeutic drugs and radiation, alternative therapies are needed, especially ones utilizing and maximizing natural products (NPs). NPs abound with diverse bioactive primary and secondary metabolites and compounds with therapeutic properties. Marine probiotics are beneficial microorganisms that inhabit marine environments and can benefit their hosts by improving health, growth, and disease resistance. Several studies have shown they possess potential bioactive and therapeutic actions against diverse disease conditions, thus opening the way for possible exploitation of their benefits through their application. Pseudoalteromonas spp. are a widely distributed heterotrophic, flagellated, non-spore-forming, rod-shaped, and gram-negative marine probiotic bacteria species with reported therapeutic capabilities, including anti-cancer and -bacterial effects. This review discusses the basic concepts of marine probiotics and their therapeutic effects. Additionally, a survey of the anticancer and antibacterial effects of Pseudoalteromonas spp. is presented. Finally, marine probiotic production, advances, prospects, and future perspectives is presented.
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DOI: 10.3390/ph16081091
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