article · Journal of Drug Delivery and Therapeutics
This study evaluated the neuroprotective properties of a fraction derived from Celtis integrifolia roots, a plant traditionally applied to relieve nervous disorders. Researchers tested the root extract on mice subjected to brain damage induced by monosodium glutamate over a 21-day period. Administration of the plant fraction boosted key antioxidant enzyme activities, specifically catalase, superoxide dismutase, and glutathione, while reducing markers of oxidative stress such as nitric oxide and malondialdehyde in brain tissue. The extract also elevated levels of acetylcholinesterase activity in treated mice relative to the untreated control group. Furthermore, examination of brain tissue revealed that the treatment prevented cell death across several brain areas, including the cortex, amygdala, and parts of the hippocampus. Overall, the findings confirm that the root fraction provides neuroprotective benefits against chemically induced neurological damage in animal models.
Neurodegenerative conditions cause extensive damage to brain cells and disrupt normal cognitive function, often driven by oxidative stress. Demonstrating that a traditionally used plant can protect brain tissue and bolster natural antioxidant defences in animal models provides scientific support for traditional medicine and identifies potential natural resources for managing neurological damage.
This work points to potential therapeutic applications in neurodegenerative disease management. It may interest pharmaceutical and nutraceutical developers seeking plant-based neuroprotective leads. However, because the findings reflect early-stage research conducted exclusively in mice, the candidate therapy remains distant from real-world medical use and requires substantial further testing, including safety evaluation and clinical trials.
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Background: Celtis integrifolia is a common plant with its roots traditionally used to alleviate nervous problems. The current study aimed to assess the potential effects on cholinergic activity and oxidative status in the brain, as well as its impact in preventing neurological damage in neurodegenerative diseases. Methodology: 35 mice were randomly distributed in seven groups (N=5). They were exposed to the monosodium glutamate (MSG) (2 g/kg/day) and given the hydrolic fraction at different doses for 21 days. The day after, CAT, SOD and GSH, NO and MDA concentrations in brain as well as the AchE activity were measured using colorimetric methods. The histoarchitectures of brain regions were also examined. Results: Compared to non-treated mice exposed to MSG (Negative), the findings of this study revealed that plant extract significantly increased the antioxidant enzymes activity (CAT, SOD and GSH) and significantly decreased the NO and MDA concentrations in brain mice exposed to MSG. Furthermore, the extract significantly increased levels of AChE activity compared to the negative control. Moreover, hydrolic fraction of C. integrifolia significantly prevented necrosis in the Ca1 and Ca3 regions hippocampal, cortex, amygdala and gyrus as well as loss of hilum of dentate gyrus in mice exposed to MSG. Conclusion: In conclusion, this study demonstrates that the hydrophilic fraction of Celtis integrifolia root has a neuroprotective effect in MSG-induced neurodegenerative-like diseases. Keywords: Celtis integrifolia; antioxidant; Brain histoarchitecture.
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DOI: 10.22270/jddt.v15i7.7243
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