The study of Hemopexin concentration as a predictor for relapsing nephrotic syndrome in children

Abstract

Background: Nephrotic syndrome (NS) is characterized by progressive loss of proteins, albumin, & other plasma components of comparable mass in patients who present with a syndrome complex, which includes elevated blood lipid concentrations, urinary lipids, & edema. The study aimed to assess the predictive value of urine Hemopexin concentration in kids with Idiopathic Nephrotic Syndrome in relation to disease recurrence and steroid response. Methods: This was a comparative study that was performed on 40 children attending Pediatric Nephrology unit & outpatient Clinic of Benha University Hospital from August 2022 to February 2023 and 20 apparently healthy control kids who were selected from outpatient clinic. Hemopexin concentrations in urine of all subjects (uHpx) were determined by ELISA. Results: An extremely significant difference in urinary hemopexin concentrations among the groups (F=701.562, p < 0.001). Both children with idiopathic NS and those with relapses have significantly higher hemopexin concentrations in urine in comparison to the control group (P1