The Role of Using Tranexamic Acid (TXA) during Thyroidectomy to Control Bleeding in Patients Diagnosed with Controlled Toxic Goiter

Abstract

Introduction: Toxic goiter is a condition that is characterized by an excessive production of thyroid hormonesby the gland, which may be diffusely enlarged, multinodular, or a solitary nodule at one lobe of the thyroid gland.Aim of work: To compare the amount of bleeding during and after thyroidectomy operations in patients diagnosedwith toxic goiter among two groups, the first group with perioperative TXA injection and the second group withplacebo injection and to asses tranexamic acid (TXA) role of hemostasis.Patients and methods: This study was conducted at the general Surgery departments of Ain Shams UniversityHospitals and the National Institute of Diabetes and Endocrine diseases. 36 patients with toxic goiter presentedto us in the outpatient clinic and fulfilling the inclusion criteria in the absence of any of the exclusion criteria allunderwent total thyroidectomy operation after controlling their medical status and anesthesiology departmentapprove their fitness of surgery.Results: This study showed that in group 1, the mean Pre-surgery hemoglobin level was 13.08±2.53 postsurgeryhemoglobin level was 12.5±2.42. In group 2, the mean Pre-surgery hemoglobin level was 13.53±2.44,post-surgery hemoglobin level was 12.1±0.36. There were significant differences between both groups as regardslaboratory data.Conclusion: injecting (TXA) has a beneficial effect During thyroidectomy. Moreover, based on the results of thepresent study, injecting this amount of (TXA) had No significant effect on post-surgery hemoglobin levels. finally,and to get more data and more valuable statistics, more studies on a larger number of cases (May be multicenter)with the same method of postoperative assessment and standardization of both inclusion and exclusion criteria.