The Relationship Between Vitamin D3 And Inflammatory Markers in Hemodialysis Patients

Abstract

Background: Vitamin D and hemodialysis patients' inflammation and inflammatory markers has been the subject of few investigations, with contradictory findings. This research aimed for assessment of the correlation between novel inflammatory markers and vitamin D levels among hemodialysis patients.Methods: Ninety-four patients on hemodialysis who had End stage renal disease (ESRD) were involved in this cross-sectional study who were classified based on vitamin D level into: Vitamin D Deficient Group (n=67) in addition to Vitamin D Sufficient/ Normal Group (n=27). The Complete blood count (CBC), C-reactive protein (CRP), serum ferritin, serum albumin, serum electrolytes, erythrocyte sedimentation rate (ESR), as well as serum 25-hydroxyvitamin D level, among other laboratory investigations were assessed with calculation of both platelet lymphocyte rate (PLR) and neutrophil lymphocyte ratio (NLR) among all patients each month prior to the first midweek dialysis appointment.Results: Higher ferritin level was found among Vitamin D deficient group versus Sufficient/ Normal group with P-value (0.0001). Vitamin D deficient group has shown Vitamin D level 10.8±2.9 vs. 28.7±6.5 in the Sufficient/ Normal group with statistically significant differences; P-value = 0.00001. The Vitamin D deficient group has shown higher levels of CRP, ESR, NLR and PLR than the Sufficient/ Normal group with statistically significant differences; (P-value = 0.014, 0.0001, 0.003 and 0.011 respectively). Conclusion: Our findings underscore the high prevalence of insufficiency of vitamin D levels among this population and their correlation with increased levels of inflammatory markers such as CRP, ESR, NLR, and PLR.