The relation between coronary artery disease and osteopenia: A study using Coronary Artery Calcium Score and Bone Mineral Density

Abstract

Background: The correlation between bone mineral density (BMD) and coronary arterial calcification (CAC) was still controversial Aim of the study: The objectives of this study were to assess the relation between coronary artery calcification and osteopenia /osteoporosis using Multidetector computed tomography (MDCT) and Dual-energy X-ray (DEXA). Patients and methods: This study was a cross sectional study included 50 patients who were recruited consecutively from the outpatient clinic in Agouza Police hospital, the recruitment time was 6 months from January 2020 till July 2020. Results: There was a weak negative correlation between Agatston CAC score and both RT hip total BMD and LT hip total BMD. Additionally, a moderate negative correlation was identified between Agatston CAC score and Lumbar spine BMD, RT femoral neck BMD, and LT femoral neck BMD in female cases. Conversely, male cases exhibited a weak negative correlation between Agatston CAC score and BMD. Furthermore, a statistically significant moderate positive correlation was found between Agatston CAC score and TG, cholesterol, alkaline phosphatase, and BMI. Conversely, a mild negative correlation was observed between Agatston CAC score and HDL levels. Notably, correlations with age, HBA1C, LDL, and calcium were non-significant. Consequently, BMI, right hip total BMD, left femoral neck BMD, and left hip total BMD were identified as significant risk factors for increased CAC score.Conclusion: The present study concluded that there was inverse association between Agatston CAC score, and BMD as increased CAC score is associated with decrease in bone mineral density which increase risk of coronary artery disease.