book chapter · BENTHAM SCIENCE PUBLISHERS eBooks
Asthma in children is associated with serious exacerbations that are modulated by inflammation. The expression of inflammatory cytokines varies according to the severity of the disease. The transition from the state of exacerbation of the disease to the state of cure always passes through a relationship between inflammatory and anti-inflammatory mediators. This study looks at the expression of IL-38 and NLRP3 inflammasome in severe childhood asthma. NLRP3 inflammasome is upregulated in severe asthma, contrasting with low levels of IL-38. The inflammatory pattern of severe asthma in children is characterized by the expression of IL-17, IL-32, IL-1β, and NLRP3 inflammasome.
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DOI: 10.2174/9789815223941124010010
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