article · Nutritional Neuroscience

The potential neuroprotective effects of <i>Spirulina platensis</i> in a valproic acid-induced experimental model of autism in the siblings of albino rats: targeting PIk3/AKT/mTOR signalling pathway

Radwa Ismail
Asmaa Fawzy Eltantawy
Eman Basha
Alaa Elkordy
Hoda A. Ibrahim
Nashwah G. M. Attallah
Walaa A. Negm
Aya Osama
Fatma H. Rizk
Sameh Magdeldin
Najla Altwaijry
Asmaa Ramadan Azzam

20243 citationsSuez Canal University

Abstract

Autistic Group (III) showed an increment in levels of MDA, IL-6, IL12 and BAX while showing a decrement in SOD, Bcl-2 and Beclin-1 as well as increased PI3k, Akt and mTOR gene expression. Autistic Group (III) also exhibited hypocellularity and disorganization of hippocampal and prefrontal cortex cells. The autistic SP-treated group (IV) showed improvement in these biochemical markers and pathological changes. Our findings suggest that <i>Spirulina platensis</i> will be significant in managing autism.

Research topics

Pancreatic function and diabetes
Autism Spectrum Disorder Research
Genetics and Neurodevelopmental Disorders

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DOI: 10.1080/1028415x.2024.2381154

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