review · Phytotherapy Research
Galangin is a naturally occurring flavonoid that displays broad biological activities, including anti-inflammatory, antioxidant, antimicrobial, antiproliferative, and metabolic benefits. Research shows that it is well tolerated and offers positive outcomes across various conditions driven by inflammation. These include disorders affecting the renal, hepatic, central nervous, cardiovascular, gastrointestinal, and respiratory systems, alongside skin conditions, ulcerative colitis, acute pancreatitis, retinopathy, osteoarthritis, osteoporosis, and rheumatoid arthritis. The anti-inflammatory action of galangin operates predominantly by suppressing key molecular pathways: p38 mitogen-activated protein kinases, nuclear factor-kappa B, and nod-like receptor protein 3 signals. Molecular docking analyses corroborate these mechanisms. While findings indicate substantial therapeutic potential for galangin as a natural anti-inflammatory agent, translational clinical research remains necessary to evaluate its safety and efficacy in human medicine.
Inflammatory disorders affect multiple organ systems and require safer, more effective treatments. Exploring plant-derived compounds such as galangin helps identify therapeutic alternatives with potentially fewer adverse effects. Understanding how this naturally occurring flavonoid regulates key inflammatory signalling pathways offers a foundation for developing new drug treatments across a broad spectrum of acute and chronic diseases.
Galangin holds potential for pharmaceutical developers aiming to create plant-derived therapies for widespread inflammatory diseases. However, the compound remains at an early, pre-clinical stage of development based on laboratory and molecular docking assessments. Significant translational and clinical research is still required before it can be validated as a safe and effective pharmaceutical product for human use.
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When used as an alternative source of drugs to treat inflammation-associated diseases, phytochemicals with anti-inflammatory properties provide beneficial impacts. Galangin is one of the most naturally occurring flavonoids. Galangin has many biological activities, such as anti-inflammatory, antioxidant, antiproliferative, antimicrobial, anti-obesity, antidiabetic, and anti-genotoxic activities. We observed that galangin was well tolerated and positively impacted disease underlying inflammation for the renal, hepatic, central nervous system, cardiovascular, gastrointestinal system, skin, and respiratory disorders, as well as ulcerative colitis, acute pancreatitis, retinopathy, osteoarthritis, osteoporosis, and rheumatoid arthritis. Galangin anti-inflammatory effects are mediated mainly by suppressing p38 mitogen-activated protein kinases, nuclear factor-kappa B, and nod-like receptor protein 3 signals. These effects are confirmed and supported by molecular docking. Clinical translational research is required to accelerate the bench-to-bedside transfer and determine whether galangin can be utilised as a safe, natural source of pharmaceutical anti-inflammatory medication for humans.
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DOI: 10.1002/ptr.7874
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