article · Toxicology Research

The modulatory effect of bee honey against diethyl nitrosamine and carbon tetrachloride instigated hepatocellular carcinoma in Wistar rats

Tarek K. Abouzed
Fayez Althobaiti
Wael M Gouda
Mohmed Atef Kassab
Ehab Eldomany
Shymaa A. Khatab
Ahmed M. El‐Gazzar
Adil Aldhahrani
Mohamed Mohamed Soliman
Samir A. El‐Shazly
Doaa Abdallha Dorghamm

20214 citationsOpen accessKafr el-Sheikh University

Abstract

The current study confirmed that honey has the potential to act as an antimetastatic factor. Bee honey supplementation either before or after combined injection of DEN/CCl4 exhibited inhibitory and ameliorative effects against DEN/CCl4-induced HCC through its antioxidant, antiproliferative, anti-metastatic, antifibrotic, and apoptosis properties. To our knowledge, this is the first study to describe the molecular mechanisms underlying honey's effects against DEN/CCl4-induced HCC in rats.

Research topics

Bee Products Chemical Analysis
Healthcare and Venom Research
Biochemical effects in animals

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DOI: 10.1093/toxres/tfab094

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