article · Scholars International Journal of Obstetrics and Gynecology
A cross-sectional study in Makurdi investigated the relationship between endometrial thickness and pregnancy outcomes in 265 women undergoing in vitro fertilisation with donor oocytes. Endometrial thickness was assessed via ultrasound and categorised into three groups: under 7 millimetres, 7 to 14 millimetres, and over 14 millimetres. While parity, body mass index, previous cycles, and embryo grading showed no significant association with outcomes, both patient age and endometrial thickness significantly influenced clinical pregnancy rates. Women with an endometrial thickness below 7 millimetres experienced a lower pregnancy rate of 37.3 percent, compared to 49.0 percent for 7 to 14 millimetres and 51.7 percent for over 14 millimetres. An endometrial thickness threshold of 8.0 millimetres provided a sensitivity of 75.4 percent and specificity of 48.8 percent, indicating that while thicker lining correlates with higher success, its predictive accuracy remains limited.
In vitro fertilisation can be costly and emotionally challenging, especially when using donor oocytes. Demonstrating how endometrial thickness affects implantation helps clinicians and patients make informed decisions about whether to proceed with embryo transfer. Recognising the limitations and predictive value of ultrasound measurements supports more tailored treatment protocols and realistic expectations for success.
The findings are applied clinical observations relevant to fertility clinics and reproductive medicine specialists. The data can inform clinical decision-making protocols and patient counselling regarding transfer timing and lining thresholds. Because this is observational research evaluating existing ultrasound methods rather than a novel product, immediate use lies in updating clinical guidelines rather than commercial technology development.
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The impact of endometrial thickness on pregnancy rates in women undergoing IVF with donor oocytes has significant implications for public health. Successful implantation during in vitro fertilization (IVF) is crucially dependent on both a healthy endometrium and a viable blastocyst. The measurement of endometrial thickness (EMT) via ultrasound scan has emerged as a non-invasive means to evaluate endometrial receptivity. Nonetheless, its significance in clinical practice for women using donor oocytes remains unclear. This study aims to examine how endometrial thickness influences pregnancy outcomes in women undergoing IVF with donor oocytes in Makurdi, with the goal of providing valuable insights for public health action. We conducted a cross-sectional study involving 265 women who underwent IVF and embryo transfer using donor oocytes. Participants were divided into three groups based on their EMT: Group 1 (EMT < 7 mm), Group 2 (EMT between 7 - 14 mm), and Group 3 (EMT > 14 mm). Key demographic and clinical data—including age, height, weight, number of oocytes transferred, and pregnancy rates—were gathered and analyzed using SPSS version 25.0. Statistical methods included Student’s t-test for continuous variables, Pearson’s Chi-square (χ²) test for categorical data, logistic regression to control for confounding factors, and Receiver Operating Characteristic (ROC) curve analysis to evaluate the predictive value of EMT. The average age of participants was 42.4 years, with chemical and clinical pregnancy rates recorded at 75.5% and 53.6%, respectively. Notable findings include a significant association between age and clinical pregnancy rates (p = 0.008). While other factors such as parity, BMI, previous IVF cycles, hormone treatments, and embryo grading did not show a significant relationship with pregnancy outcomes but endometrial thickness demonstrated a significant correlation (p = 0.000). Specifically, pregnancy rates were lower for women with EMT < 7.0 mm (37.3%) compared to those with EMT between 7 - 14 mm (49.0%) and > 14 mm (51.7%). Logistic regression confirmed that age-adjusted EMT significantly impacts pregnancy outcomes. ROC curve analysis revealed an area under the curve (AUC) of 0.63, with an EMT cut-off value of 8.0 mm providing a sensitivity of 75.4% and a specificity of 48.8%. These findings highlight the significant influence of endometrial thickness on clinical pregnancy rates in IVF cycles using donor oocytes. While increased EMT correlates with improved outcomes, its overall predictive accuracy is limited. The results advocate for personalized approaches in IVF treatment protocols, emphasizing informed decision-making among healthcare providers and patients. Recognizing the importance of endometrial thickness in reproductive health can inform public health initiatives aimed at enhancing awareness of IVF practices among potential candidates, tailoring IVF treatments based on individual patient profiles, and promoting research into factors affecting endometrial receptivity. Ultimately, these efforts can lead to improved pregnancy rates and reproductive success in assisted reproductive technologies.
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DOI: 10.36348/sijog.2025.v08i05.004
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