review · Infezioni in Medicina
This literature review examines the emergence and characteristics of SARS-CoV-2 Omicron subvariants, including BA.1, BA.2, and BA.3, which rapidly became dominant globally due to their high infectivity and ability to evade immunity. The review compares these subvariants based on their structural variations, mutations, clinical manifestations, transmissibility, pathogenicity, and vaccine effectiveness. A key distinction is the absence of the Δ69-70 deletion in the spike protein of some subvariants, affecting S gene target failure detection. BA.2 showed a stronger affinity to the human ACE2 receptor and, along with BA.3, exhibited greater transmissibility than BA.1 and BA.1.1. BA.1.1 had the highest number of mutations. These features explain Omicron's widespread geographical reach and high contagiousness.
Understanding the distinct characteristics of SARS-CoV-2 Omicron subvariants is crucial for public health. This knowledge helps in tracking viral evolution, assessing transmission risks, and informing strategies for disease control, vaccine development, and diagnostic testing, ultimately aiding in managing the ongoing pandemic.
The abstract provides a literature review of the characteristics of SARS-CoV-2 Omicron subvariants. It does not indicate any specific application pathways for commercialisation, such as new products, services, or technologies.
AI-generated from the published abstract. Always read the original work before citing.
The SARS-CoV-2 Omicron variant (B.1.1.529) has been the most recent variant of concern (VOC) established by the World Health Organization (WHO). Because of its greater infectivity and immune evasion, this variant quickly became the dominant type of circulating SARS-CoV-2 worldwide. Our literature review thoroughly explains the current state of Omicron emergence, particularly by comparing different omicron subvariants, including BA.2, BA.1, and BA.3. Such elaboration would be based on structural variations, mutations, clinical manifestation, transmissibility, pathogenicity, and vaccination effectiveness. The most notable difference between the three subvariants is the insufficiency of deletion (Δ69-70) in the spike protein, which results in a lower detection rate of the spike (S) gene target known as (S) gene target failure (SGTF). Furthermore, BA.2 had a stronger affinity to the human Angiotensin-converting Enzyme (hACE2) receptor than other Omicron sub-lineages. Regarding the number of mutations, BA.1.1 has the most (40), followed by BA.1, BA.3, and BA.3 with 39, 34, and 31 mutations, respectively. In addition, BA.2 and BA.3 have greater transmissibility than other sub-lineages (BA.1 and BA.1.1). These characteristics are primarily responsible for Omicron's vast geographical spread and high contagiousness rates, particularly BA.2 sub-lineages.
This page summarises published work. The authoritative version sits with the publisher.
DOI: 10.53854/liim-3004-2
Is something wrong with this record? Report it or request removal.
Discussion
Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.
No discussion yet. Open the first thread.
New to MARATTO™? Create a free account.
