article · Scientifica
Urinary tract infections present growing treatment difficulties due to escalating antimicrobial resistance among causative bacteria. A study of 141 patients suspected of having urinary tract infections at Pawe General Hospital in Northwest Ethiopia examined bacterial prevalence and resistance profiles. Significant bacteriuria occurred in 20.6 percent of the participants. Escherichia coli was the most common pathogen, representing 42.6 percent of isolates, followed by Klebsiella and Pseudomonas species at 10.7 percent each. Outpatient bacterial isolates demonstrated high resistance rates to amoxicillin-clavulanic acid at 64 percent and tetracycline at 78.6 percent. Inpatient strains showed 63.9 percent resistance to cephalexin and 87.2 percent to tetracycline. Almost all isolates displayed a multiple antimicrobial resistance index above 0.20. Despite this resistance, most isolates remained susceptible to ceftriaxone, gentamicin, ciprofloxacin, nitrofurantoin, and norfloxacin, indicating their continued value for empirical therapy.
Rising resistance among bacterial pathogens narrows the therapeutic options available to treat everyday infections. Identifying local bacterial profiles and resistance trends helps healthcare providers select effective empirical treatments, avoid ineffective antibiotics, and prevent complications. Routine monitoring of drug susceptibility provides essential evidence for clinicians to safeguard public health and preserve the efficacy of critical antimicrobial treatments.
The findings inform local hospital formularies, diagnostic laboratories, and regional healthcare procurement by specifying which antibiotics remain effective and which face substantial resistance. This surveillance data is applied clinical research that directly guides local treatment guidelines, though the abstract does not indicate any product development, intellectual property, or commercial technology pathway.
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Urinary tract infection remains the most common infection widespread worldwide in both community and hospital settings. Rapidly increasing antibiotic resistance of uropathogens is resulting in limited treatment options. Thus, understanding the current uropathogens and their antimicrobial susceptibilities is essential for effective urinary tract infection treatment. The purpose of this study was to isolate, characterize, and determine the antimicrobial susceptibility patterns of bacterial pathogens associated with urinary tract infection at Pawe General Hospital in Northwest Ethiopia. A hospital-based cross-sectional study design was conducted from January to April, 2020, at Pawe General Hospital. Midstream urine specimens were collected from 141 individuals with suspected urinary tract infection for bacteriological identification and antimicrobial susceptibility testing. Among the 141 study participants, twenty-nine (20.6%) showed significant bacteriuria. Escherichia coli (42.6%) had the highest proportion of isolated uropathogen followed by Klebsiella spp. and Pseudomonas spp. each (10.7%); Proteus spp. (9.3%); coagulase negative staphylococci, Staphylococcus aureus, and Enterobacter spp. each (6.7%); Citrobacter spp. (4%); and Enterococcus faecalis and Streptococcus spp. each (1.3%). Outpatient isolates showed a resistance of 64% and 78.6% to amoxicillin-clavulanic acid and tetracycline, respectively. Inpatients showed 63.9% and 87.2% of resistance to cephalexin and tetracycline. It was also observed that all the isolates have a multiple antimicrobial resistance index greater than 0.20 except Citrobacter spp. (0.142) in inpatients. Even though in this locality, most isolates were sensitive to ceftriaxone, gentamicin, ciprofloxacin, nitrofurantoin, and norfloxacin, they are considered appropriate antimicrobials for empirical treatment of urinary tract bacterial infections. Periodic monitoring of etiology and drug susceptibility is highly recommended, along with health education on the transmission and causes of urinary tract infection.
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DOI: 10.1155/2022/3085950
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