article · Applied Organometallic Chemistry
A novel selenated azomethine ligand known as MSeOH and its metal chelates containing zinc, iron, and copper were prepared and structurally verified. Confirmation of their chemical frameworks relied on techniques including X-ray diffraction, thermal analysis, molar conductivity, and spectroscopic analyses comprising infrared, nuclear magnetic resonance, and mass spectrometry. Beyond chemical characterisation, biological evaluations were performed to measure the antitumor and antimicrobial effectiveness of the compounds across various mammalian cells and pathogenic strains. In addition, antioxidant capacities were assessed through DPPH and SOD bioassays. Theoretical assessments using density functional theory clarified molecular structure, bonding behaviours, polarity, reactivity, and electronic characteristics. Together, the experimental and computational findings indicate that both the selenated ligand and its metal complexes display promising biological activities.
The development of new metal-based compounds offers potential avenues for tackling infectious pathogens and cancer cell growth. By integrating selenium into azomethine ligands paired with essential metals, researchers can identify chemical structures that exhibit dual therapeutic and protective antioxidant capabilities, providing a foundation for future health-related discoveries.
The research is at an early experimental stage, focusing on laboratory synthesis and in vitro screening. The findings could eventually interest pharmaceutical developers working on new oncology treatments, antimicrobial agents, or antioxidant therapies. However, substantial preclinical validation, safety testing, and formulation development will be required before any commercial or clinical use can be pursued.
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ABSTRACT Novel selenated azomethine ligand (MSeOH) and its Zn(II), Fe(II), and Cu(II) chelates were synthesized. Their chemical structures were confirmed by molar conductivity, thermal analysis, X‐ray diffraction, IR, NMR, and MS spectroscopic techniques. The antitumor and antimicrobial properties were evaluated against various mammalian cells and pathogenic strains. Furthermore, the antioxidant activities were also assessed using DPPH and SOD bioassays. To gain a deeper understanding of the molecular structure and electronic properties of these complexes, a density functional theory (DFT) study was conducted. The parameters examined in this study provide valuable insight into the bonding, electronic properties, reactivity, and polarity of the compounds under investigation. The biological and theoretical results point to promising activities of the selenated ligand and its complexes.
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DOI: 10.1002/aoc.7712
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