article · RSC Advances

Synthesis, characterization, <i>in vitro</i> and computational assessment of new xanthene hydrazone derivatives as promising vasorelaxant agents

Mohammed El Mesky
John P. Giesy
Sahar Abdulaziz AlSedairy
Yassine Rhazi
Hicham Zgueni
Samir Chtita
Mohammed Chalkha
Driss Chebabe
Mourad A. M. Aboul-Soud
Farid Khallouki
Ismail Bouadid
Fatimazahra Guerguer
El Houssine Mabrouk
Mohamed Eddouks

2026Open accessUniversité Moulay Ismail de Meknes

Abstract

findings suggest that F3 and F4 possess acceptable ADMET properties, supporting their potential as promising drug candidates. Overall, the results indicate that these functionalized xanthene-hydrazone derivatives represent a promising foundation for the development of novel vasorelaxant agents.

Research topics

Natural Compound Pharmacology Studies
Nitric Oxide and Endothelin Effects
Phytochemistry Medicinal Plant Applications

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DOI: 10.1039/d6ra01067a

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