Synthesis, Characterization, DFT, TEM, Anticancer, Antibacterial, and Electrical Properties Studies of Novel VO(II), Cu(II), Ru(III), and Ag(I) Complexes With Hydrazone Derivatives

Abstract

ABSTRACT Four new VO(II), Cu(II), Ru(III), and Ag(I) chelates were created from the ligand, 2‐(phenylglycyl)‐N‐(p‐tolyl)hydrazine‐1‐carbothioamide(H 2 L). The structures of the new compounds were investigated using analytical and spectroscopic techniques and supported by the theoretical DFT study. In addition, all compounds exhibited strong anticancer effects against liver (Hep‐G2), breast (MCF‐7), and colon (HCT‐116) human cancer cell lines. VO(II) complex observed the greatest activity with IC 50 reached to 14, 19, and 20 μM against Hep‐G2, MCF‐7, and HCT‐116 cell lines, respectively. Molecular docking confirmed the resulted anticancer results. Also, the compounds observed microbial growth inhibition against S. pyogenes and E. coli organisms. The transmission electron microscope (TEM) demonstrated that the pure ligand's particle size decreased when it formed complexes with various metals. The electrical examination of complexes involved measuring their conductivity and dielectric characteristics to explore their application in electrical devices.