Synthesis, characterization and biological activity of cadmium (II) complex of hydrazone moiety

Abstract

With the aid of hydrazone moiety, a novel Cd(II) chelate with 2-[(4-methylphenyl)amino]-N'-[(Z)-thiophen-2-ylmethylidene]acetohydrazide (H2L) was created and reported. These novel chemicals' structural makeup was clarified through the utilization of spectroscopic and analytical methods. The chelates were molded with a molar ratio of 1:1 M:L and the formula [Cd(H2L)Cl2]. Cd(II) complex of the biological activity ligand is investigated. Theoretical measurements supported the proposed generic formula for the [Cd(H2L)Cl2] complex. The compound's anticancer and antibacterial properties were evaluated using cisplatin, gentamicin, and ampicillin as standards. It was found that the Cd 2+ complex was more effective against two cancer cell lines and several bacterial strains than it was against ligand. The results showed that the compound's activities were: Cd(II) complex > H2L, with Cd(II) complex exhibiting the maximum activity. By examining the binding between the complex and Penicillin-binding protein PBP, which is primarily thought of as the production of the cell wall through its transglycosylation and transpeptidation, a molecular docking study was carried out to support the microbial inhibition growth.