Synthesis, characterization, and antiproliferative activities of new transition metal complexes with 3-((4-fluoro-2-hydroxybenzylidene)amino)-2-thioxoimidazolidin-4-one

Abstract

The utilization of the (fluorosalicylidene)-aminothiohydantoin (FSATH) ligand has been employed in the synthesis of several coordination compounds containing Mn(II), Co(II), Cu(II), and Zn(II) ions. This is achieved by reacting the ligand with metal(II) chlorides in a stoichiometric ratio of 1:1. Through the application of diverse physicochemical and spectroscopic techniques, our investigation focused on examining the coordination properties of FSATH in the presence of M(II) ions. Additionally, we aimed to determine the stoichiometry and stereochemistry of the resulting metal coordination compounds. Thermogravimetric analysis (TGA) and differential thermal analysis (DTA) techniques have been employed to investigate the thermal stability of both the unbound ligand and its coordination compounds. The results of the study indicate that the cytotoxicity of all coordination compounds tested against human breast cancer cell lines (MCF-7) was higher compared to that of the parent ligands. These findings suggest that these coordination compounds have the potential to be considered as promising candidates for the development and investigation of novel chemotherapeutic agents in the field of cancer therapy, as demonstrated by the comparative in-vitro anticancer studies conducted. Cu-FSATH demonstrates significant cytotoxicity against MCF-7, making it a highly promising candidate as an alternative to conventional chemotherapeutic agents.