article · Dutse Journal of Pure and Applied Sciences
Researchers synthesised mixed ligand coordination complexes combining manganese(II) ions with salicylhydroxamic acid and oxalic acid. Physical and chemical testing showed that the resulting complexes were soluble in methanol and ethanol, while dimethyl sulfoxide remained inert under water and chloroform. The melting points for the mixed complexes and salicylhydroxamic acid fell within the range of 180 to 300 degrees Celsius. Spectroscopic analyses confirmed the chemical structures, identifying key carbonyl, alkene, and carbon-oxygen bonds, alongside hydroxyl and metal-oxygen coordinations, with ultraviolet-visible spectroscopy showing maximum absorbance at 300 nanometres. When evaluated using agar disc diffusion methods against four bacterial species, including Staphylococcus aureus and Escherichia coli, and two fungal strains, including Candida albicans, the manganese(II) complexes demonstrated clear zones of inhibition, exhibiting effective antimicrobial activity against all tested microorganisms.
Developing new antimicrobial compounds is important for identifying novel treatments against common bacterial and fungal pathogens. By synthesising and characterising mixed manganese complexes that inhibit organisms like Staphylococcus aureus and Candida albicans, this work provides basic chemical data on how specific ligand combinations can yield compounds with bioactive properties against medically relevant microbes.
This research represents early-stage laboratory discovery. The synthesised complexes could eventually inform the design of antimicrobial agents or pharmaceutical ingredients targeting bacterial and fungal infections. Potential future users include pharmaceutical researchers developing therapeutic candidates. However, the work remains at a preliminary in vitro stage, requiring substantial additional validation, toxicity testing, and clinical assessment before any practical commercial application can be pursued.
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Several synthesized metal ions of transition metals from mixed ligand form complexes due to coordination bond which can be soluble in polar or non- polar solvents depending on conditions. This study was aimed to synthesis ligands of salicylhyroxamic acid (SHA) and oxalic acid that formed Mn (II) ion complexes. The solubility test on yielded complexes showed positive effects on methanol, ethanol while Di- methyl sulfoxide (DMSO) became inert under distilled water and chloroform. Melting point test revealed that mixed complexes and SHA are within the temperature range of 180oC to 300oC respectively. The functional group present in complexes investigated using FTIR showed C=O, C=C and C-O stretching’s with O-H and M-O coordination’s. The complexes was characterized using UVvisible where peaks of the ligands and the mixed complexes in DMSO showed the maximum absorbance at 300 nm, whose concentrations have uniform horizontal values that indicated the n→∏* transition of the ligand SHA. The antimicrobial activity tested on the ligand SHA (C7H7NO3), complexes and reference drug investigated against four bacterial species; staphylococcus aureus, Escherichia coli, Klebsilla pneumonia and Salmonella typhi and two fungi species candida albicans and Aspergillus niger that involved agar disc diffusion methods showed diameter of inhibitions zone of individual sample analyte are dignified. A momentous activity of Mn (II) complexes observed on investigated micro-organisms of the mixed complexes syntheses showed effective anti-microbial agent in this research.
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DOI: 10.4314/dujopas.v11i1c.32
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