Surfactant Catalysis of Phloroglucinol Oxidation With Pyrosulphate Ion: Piszkiewicz's, Raghavan–Srinivasan's, and Portnoy–Menger Models

Abstract

ABSTRACT Phloroglucinol (PGN) oxidation can result in accelerated lipid peroxidation, leading to oxidative stress and cellular damage (including protein carbonylation and DNA damage). Hence, its oxidation in a surfactant environment is investigated to ascertain its reaction character and property kinetically using spectrophotometric method. The PGN oxidation with pyrosulphate ion (S 2 O 7 2− ) exposes the possibility of electrostatic, hydrophobic, or hydrophilic behaviour in a micelle host. The investigated kinetic functions expose first‐order‐kinetics in respect of PGN and S 2 O 7 2− concentrations, and an equally shared mole ratio between PGN and S 2 O 7 2− ions. The increment in electrolyte level has no impact on the oxidation rate, and the increase in acid concentration accelerates the oxidation rate, whereas the aggregation of surfactant monomers (cetyltrimethylammonium bromide, CTAB) assists the oxidation rate. The PGN and S 2 O 7 2− ions binding state ( K B = 0.8445; K PGN = 0.4633, K PS = 0.9265; K B = 0.2849) with the CTAB‐micelles is anchored by Piszkiewicz's, Raghavan–Srinivasan's, and Portnoy–Menger models, respectively. The involvement of intermediate species and substrate radicals is deniable and undeniable, accordingly. The thermodynamic feasibility of the oxidation process is verified by the thermodynamic parameters (Δ G = + 70.98 kJmol −1 , Δ H * = + 32.69 kJmol −1 , and Δ S * = − 128.05 JK −1 mol −1 ) and non‐spontaneity leads the process.