Study the Association between Serum Asymetrical Dimethylarginine Level and Cardiac Functions in Chronic kidney Disease Patients

Abstract

Background: It is well known that cardiovascular disease is the leading cause of death for those who suffer from chronic renal disease, making it a pressing global public health concern. Human blood contains a naturally occurring modified amino acid called asymmetric dimethylarginine (ADMA). It may have a significant role in the development of atherosclerosis by preventing the body from producing nitric oxide, a gas essential for maintaining healthy vascular tone.Objectives: This research aimed to examine the correlation between ADMA levels in the blood and heart function as measured by tissue Doppler imaging in patients with chronic renal disease.Patients and methods: Ninety individuals were enrolled in our study from the National Institute of Nephrology and Urology's outpatient clinics and inpatient units. All patients underwent a thorough history and physical examination as well as laboratory tests, echocardiography, and Tissue Doppler imaging. Results: There are a highly significant difference among three groups as regard as serum Creatinine level, estimated GFR, serum calcium PTH, serum ADMA, IVSD, LAD, Septal Peak E' and Lateral Peak E'. There is a positive correlation with between ADMA and serum PO, and a negative correlation between ADMA and lateral peak E.Conclusion: Tissue Doppler imaging is considered to be more accurate than echocardiography in estimating diastolic function, and serum ADMA is inversely correlated with diastolic function in CKD patients.