Study and Clinical Significance of Urinary Levels of Glypican 5 in Diabetic Patients

Abstract

Objective: To evaluate the urinary GPC5 level in T2DM as an early marker for DN. Background: Diabetic nephropathy (DN) is one of the most serious long-term consequences of type 2 diabetes mellitus (T2DM) because it causes end-stage renal disease. Methods: This cross-sectional study was done on 90 individuals, classified equally into three groups: Group 1: T2DM patients with DN, group 2: T2DM patients without DN and group 3: healthy controls without DM. They underwent [serum creatinine (sCr), serum glycated haemoglobin (HbA1c), urinary albumin to creatinine ratio (ACR), estimated glomerular filtration rate (eGFR), total cholesterol (TC), high density lipoproteins (HDL), low density lipoproteins (LDL) and triglycerides (TG), 2-hours postprandial blood glucose (2h PPG)) and fasting blood glucose (FBG) and uinary GPC5 creatinine ratio] assessment. Results: Systolic blood pressure, FBG, 2h PPG, HbA1c, TG, and urinary GPC5 creatinine ratio were significantly elevated in DN group than in the diabetics without DN and the controls, and significantly elevated in the diabetics without DN than in the controls (P