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article · bioRxiv (Cold Spring Harbor Laboratory)

Structural Brain Network Alterations in Relation to Treatment and Illness Severity in Bipolar Disorder

Abstract

As the largest structural connectivity study in BD, we reveal widespread disruption in reward and emotion-regulation networks influenced by illness severity and medication use. Results show that multisite harmonization is feasible and highlight ENIGMA-BD as a scalable framework for identifying reproducible neurobiological markers.

Research topics

  • Bipolar Disorder and Treatment
  • Functional Brain Connectivity Studies
  • Mental Health Research Topics

Sustainable Development Goals

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DOI: 10.64898/2026.03.28.714565

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