article · Materials Advances

Sorafenib nanocrystals enhance bioavailability and overcome multidrug resistance in liver cancer cells: an approach based on <i>P</i> -gp inhibition strategy

Mohamed Nasr
Heba I. Elagamy
Ahmed Gaafar Ahmed Gaafar
Sameh Saber
Soha M. El-Masry
Ahmed A.E. Mourad
Haydy Asad
Shaimaa K. Mostafa

20251 citationOpen accessDelta University for Science and Technology

In plain language

The abstract on record is too brief for a reliable plain-language summary, so none has been generated.

Abstract

This research aimed to improve the oral bioavailability of Sorafenib (SF) and overcome multidrug resistance in hepatocellular carcinoma cells based on P -glycoprotein ( P -gp) inhibition strategy.

Research topics

Drug Transport and Resistance Mechanisms
Nanoparticle-Based Drug Delivery
Computational Drug Discovery Methods

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DOI: 10.1039/d5ma00122f

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