SOFT TISSUE AND BONE REGENERATION OF RESIDUAL BONE DEFECT AFTER ERADICATION OF JAW CYSTS IN THE PRESENCE AND ABSENCE OF ALBUMIN PLATELET-RICH FIBRIN (A RANDOMIZED CONTROLLED CLINICAL TRIAL)

Abstract

Introduction: Platelets are crucial to the healing process of wounds. Accordingly, the orientation towards using platelet concentrates in healing has become familiar. Thus, a new material has been evoked known as albumin platelet-rich fibrin (Alb-PRF), which remains stable for up to 4 months and allows growth factors to be released for a long time, promoting the healing of both soft and hard tissues at the injured areas. Objective: to demonstrate how Alb-PRF affects soft and hard tissue recovery following the eradication of jaw cysts.Materials and Methods: This study contained 20 participants, divided equally into 2 groups. The study group was managed with cyst eradication followed by Alb-PRF application, while the control group was managed with cyst eradication and primary closure of the wound. According to the healing Landry index, soft tissue healing was evaluated on the 7th and 14th days. A postoperative immediate and post-6-month CBCT were performed to measure the 3-dimensional volumetric analysis of the bone defect after cyst eradication.Results: On the 7th and 14th days after the surgery, the difference was not statistically significant in soft tissue healing between both groups, P1 = 0.739 and P1 = 0.393, respectively. The change in the 3-dimensional volumetric analysis of bone defect after cyst eradication revealed that, six months later, there was no statistically significant difference between the two groups (t = 1.601, P1 = 0.130).Conclusion: According to this study, the soft and hard tissues healed properly using Alb-PRF or natural blood clots after jaw cyst eradication.