Sodium alginate/carboxymethylcellulose gel formulations containing <i>Capparis sepieria</i> plant extract for wound healing

Abstract

<b>Aim:</b> Using appropriate wound dressings is crucial when treating burn wounds to promote accelerated healing.<b>Materials & methods:</b> Sodium alginate (SA)-based gels containing Carboxymethyl cellulose (CMC) and Pluronic F127 were prepared. The formulations. SA/CMC/Carbopol and SA/CMC/PluronicF127 were loaded with aqueous root extract of <i>Capparis sepiaria</i>. The formulations were characterized using appropriate techniques.<b>Results:</b> The gels' viscosity was in the range of 676.33 ± 121.76 to 20.00 ± 9.78 cP and <i>in vitro</i> whole blood kinetics showed their capability to induce a faster clotting rate. They also supported high cell viability of 80% with cellular migration and proliferation. Their antibacterial activity was significant against most bacteria strains used in the study.<b>Conclusion:</b> The gels' distinct features reveal their potential application as wound dressings for burn wounds.