Shining a Special Light on an Unusual Case of Thoracic Lymphadenopathy

Abstract

Amyloidosis is an uncommon disease characterized by the buildup of misfolded protein fibrils outside cells in various tissues. Its diagnosis relies on tissue biopsy confirmation. Due to its diverse clinical presentations, diagnosis is often delayed. The symptoms depend on the organs affected, with the kidney and heart being most frequently involved. Although pulmonary involvement occurs relatively often, it seldom causes symptoms. Pulmonary amyloidosis can manifest as nodular pulmonary amyloidosis, diffuse alveolar-septal amyloidosis, or tracheobronchial amyloidosis. This case highlights a rare incidental finding of isolated amyloid lymphadenopathy without additional pleuropulmonary disease.