article · Journal of Pharmacy and Pharmacology

Shikonin mitigates cyclophosphamide-induced cardiotoxicity in mice: the role of sirtuin-1, NLRP3 inflammasome, autophagy, and apoptosis

Fatemah A. Alherz
Ahmed M. Kabel
Mona Y. Alsheikh
Hany M. Borg
Asmaa Saleh
Maaly A. Abd Elmaaboud

20245 citationsKafr el-Sheikh University

In plain language

The abstract on record is too brief for a reliable plain-language summary, so none has been generated.

Abstract

Shikonin may be used as an adjuvant to cyclophosphamide in cancer treatment, but further research is needed to investigate its effects on cardiotoxicity in distinct animal cancer models.

Research topics

Chemotherapy-induced cardiotoxicity and mitigation
Chemotherapy-induced organ toxicity mitigation
Bioactive Compounds and Antitumor Agents

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DOI: 10.1093/jpp/rgae119

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