review · Pharmaceutics
This review examines Self-Emulsifying Drug Delivery Systems (SEDDS), an innovative method for enhancing the solubility and bioavailability of poorly water-soluble drugs. It details the evolution from liquid SEDDS (L-SEDDS), which improve drug absorption but face stability issues, to solid SEDDS (S-SEDDS), which overcome these limitations by offering improved stability, scalability, and patient compliance. The review covers formulation strategies, characterisation techniques like droplet size analysis, and preparation methods such as spray drying. It also explores future trends, including 3D printing, hybrid systems, and supersaturable SEDDS, highlighting their potential for diverse and personalised therapeutic applications. Computational modelling is noted as a tool for optimising formulations.
Many important medicines are poorly absorbed by the body, limiting their effectiveness. SEDDS offer a way to significantly improve how these drugs are delivered and utilised, potentially leading to more effective treatments and better patient outcomes, especially for personalised medicine approaches.
This research is foundational for developing advanced drug delivery systems, particularly for poorly soluble drugs. It could lead to new pharmaceutical products with enhanced stability and patient compliance, such as personalised 3D-printed medicines or targeted drug delivery systems. The work appears to be in the applied research and development phase, with challenges like scalability and excipient toxicity still being addressed before widespread market adoption.
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Self-emulsifying drug delivery systems (SEDDS) represent an innovative approach to improving the solubility and bioavailability of poorly water-soluble drugs, addressing significant challenges associated with oral drug delivery. This review highlights the advancements and applications of SEDDS, including their transition from liquid to solid forms, while addressing the formulation strategies, characterization techniques, and future prospects in pharmaceutical sciences. The review systematically analyzes existing studies on SEDDS, focusing on their classification into liquid and solid forms and their preparation methods, including spray drying, hot-melt extrusion, and adsorption onto carriers. Characterization techniques such as droplet size analysis, dissolution studies, and solid-state evaluations are detailed. Additionally, emerging trends, including 3D printing, hybrid systems, and supersaturable SEDDS (Su-SEDDS), are explored. Liquid SEDDS (L-SEDDS) enhance drug solubility and absorption by forming emulsions upon contact with gastrointestinal fluids. However, they suffer from stability and leakage issues. Transitioning to solid SEDDS (S-SEDDS) has resolved these limitations, offering enhanced stability, scalability, and patient compliance. Innovations such as personalized 3D-printed SEDDS, biologics delivery, and targeted systems demonstrate their potential for diverse therapeutic applications. Computational modeling and in silico approaches further accelerate formulation optimization. SEDDS have revolutionized drug delivery by improving bioavailability and enabling precise, patient-centric therapies. While challenges such as scalability and excipient toxicity persist, emerging technologies and multidisciplinary collaborations are paving the way for next-generation SEDDS. Their adaptability and potential for personalized medicine solidify their role as a cornerstone in modern pharmaceutical development.
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DOI: 10.3390/pharmaceutics17010063
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