article · Journal of Materials Research and Technology
Selenium nanoparticles produced via a green microwave method using ascorbic acid show potential for both environmental and biomedical uses. The particles exhibit semi-spherical structures measuring between 8.5 and 22 nanometres, forming larger spherical agglomerates. In environmental degradation tests, 10 milligrams of the nanoparticles achieved complete removal of Fuchsin Basic dye from water within 34 minutes under visible light irradiation. Laboratory evaluations also demonstrated notable antioxidant capability through radical scavenging. Tests on human fibroblast cell lines showed that cell viability remained at roughly 75 percent at a concentration of 500 micrograms per millilitre. Antibacterial screening revealed effectiveness against multiple bacterial strains, producing the highest activity against Escherichia coli, although the particles showed no activity against Staphylococcus aureus. These combined traits support their development for skin and wound treatments.
Green manufacturing routes for nanomaterials offer sustainable pathways for both healthcare and environmental remediation. By combining efficient dye degradation under visible light with antioxidant and antibacterial actions, these selenium nanoparticles provide a dual-benefit material. Understanding their biological safety on human skin cells helps establish baseline parameters for future wound-care treatments and safer industrial wastewater management.
The findings suggest applications in topical wound and skin care formulations, as well as light-activated industrial wastewater treatment for dye removal. Potential users include manufacturers of advanced wound dressings and water purification companies. Because the evidence is based entirely on in vitro cell cultures and laboratory-scale degradation assays, this technology remains at an early research stage, requiring substantial formulation development, safety profiling, and in vivo testing before practical use.
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Selenium nanoparticles (SeNPs) were fabricated using a green microwave technique in the presence of ascorbic acid. The morphological features indicated that the semi-spherical SeNPs with a diameter 8.5–22 nm were configured in agglomerated spherical shapes with diameters around 0.47–0.71 μm. Furthermore, the removal of Fuchsin Basic dye from aqueous solutions was investigated upon variation of concentration of SeNPs. The degradation efficiency achieved 100% for 10 mg of SeNPs after 34 min of visible light irradiation time. The antioxidant activity was tested via DPPH radical scavenging assay and displayed that the highest scavenging capacity (311.1 ± 15.72 mg/g) was achieved by SeNPs at a concentration of 106.25 mg/mL. Otherwise, the cell viability of SeNPs through human fibroblasts cell lines in-vitro was reduced to be 75.1 ± 3.8% with nanoparticle concentration around 500 μg/mL. The antibacterial activity was investigated against gram-negative and gram-positive bacteria such as Escherichia coli (E.coli), Pseudomonas aeruginosa (P. aeruginosa), Klebsiella pneumoniae (K. pneumonia), Staphylococcus aureus (S. aureus), and Bacillus subtilis (B. subtilis) bacteria after one day of exposure. It was illustrated that SeNPs did not display an activity towards Staphylococcus aureus, while it possessed the highest one against Escherichia coli with MBC of 50 ± 1.76 μg/mL compared with 26 ± 0.6 μg/mL for the standard antibiotic. These tremendous properties of SeNPs indicate that manipulating multifunctional nanoparticles for versatile wound and skin treatment applications is highly encouraging.
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DOI: 10.1016/j.jmrt.2020.12.098
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