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review · European Clinical Respiratory Journal

Safety and efficacy of glucagon-like peptide-1 receptor agonists in patients with obstructive sleep apnea: a systematic review and meta-analysis of randomized controlled trials

202511 citationsOpen accessMenoufia University

Abstract

GLP-1 agonists, including tirzepatide, improved Apnea/Hypopnea Index, weight, and systolic blood pressure in adults with moderate-to-severe OSA. However, the evidence remains limited to two published studies comprising three randomized controlled trials using different pharmacological agents. Consequently, further research is needed before firm conclusions can be drawn.

Research topics

  • Obstructive Sleep Apnea Research
  • Neuroscience of respiration and sleep
  • Gastroesophageal reflux and treatments

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DOI: 10.1080/20018525.2025.2484048

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