article · Frontiers in Pharmacology

S1PR4-dependent effects of Etrasimod on primary human myeloid immune cell activation

Fiona Sailer
Aissa Miriam Röhrig
Megan A. Palmer
Dariusz Stepniak
Simeon Ramsey
Jan Heering
Anette Brockmann
Bernhard Brüne
Mohammed A.F. Elewa
Blerina Aliraj
Ewgenij Proschak
Andreas Weigert

2025Open accessKafr el-Sheikh University

In plain language

The abstract on record is too brief for a reliable plain-language summary, so none has been generated.

Abstract

Taken together, our data show that S1PR4 takes on an essential role in the regulation of various immunological functions, and that Etrasimod can act as a superagonist/functional antagonist of S1PR4.

Research topics

Research on Leishmaniasis Studies
Immune Cell Function and Interaction
Cytokine Signaling Pathways and Interactions

Read the original research

This page summarises published work. The authoritative version sits with the publisher.

View on publisher site Record on OpenAlex

DOI: 10.3389/fphar.2025.1590816

Is something wrong with this record? Report it or request removal.

Discussion

Discuss this research

Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.

No discussion yet. Open the first thread.

New to MARATTO™? Create a free account.