article · RSC Medicinal Chemistry

Rosavin improves insulin resistance and alleviates hepatic and kidney damage <i>via</i> modulating the cGAS-STING pathway and autophagy signaling in HFD/STZ-induced T2DM animals

Hebatallah S. Ali
Hind A. ELsawi
Marian Maher Salib Roushdy
Amany Helmy Hasanin
Eman K. Habib
Heba Fikry
Rasha A. Elmansy
Ghada Ellithy
Mohamed Elesawi
Mariam B. Abouelkhair
Ghida Hassan
Lobna A. Saleh
Doaa M. A. Elzoghby
Shaimaa Hamady
Hiba S. Al-Amodi
Hala F. M. Kamel
Laila M. Farid
Enshrah M. E. Ahmed
Hagir H. T. Ahmed
Marwa Matboli

20248 citationsOpen accessBadr University in Cairo

Abstract

: Rosavin has shown potential in attenuating T2DM, inhibiting inflammation in the liver and kidneys, and improving metabolic disturbances in a T2DM animal model. The observed effect was linked to the activation of autophagy and suppression of the cGAS-STING pathway.

Research topics

Medicinal Plants and Bioactive Compounds
Pharmacological Effects of Natural Compounds
Inflammasome and immune disorders

Sustainable Development Goals

Good Health and Well-being

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DOI: 10.1039/d4md00023d

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