Role of Progesterone and Inhibin A in Predicting the Adverse Outcome of Pregnancy

Abstract

Background: The prediction of future miscarriages in patients who have had a first-trimester abortion can be improved by measuring levels of inhibin A and progesterone. Pregnancy outcomes can be improved by using this important information to direct clinical treatment and care Objective. Progesterone and Inhibin A during the first trimester can be used to quickly and precisely detect pregnancy outcomes, improving prenatal services. Methods: A total of 180 women from Badr City Hospital participated in the study, split up into two groups: group b contained ninety women who had undergone a first-trimester abortion, and group a comprised ninety well-being expectant mothers. The cases was carefully evaluated by comprehensive medical history, cervical-pelvic examinations, and transvaginal ultrasound. Enzyme-linked immunosorbent assay (ELISA) was used to measure the concentrations of progesterone and inhibin A in blood samples. The goal of the study was to compare the two groups' hormone levels. Results: The findings of the study indicate that low progesterone levels, high diastolic blood pressure, previous abortions, and primigravida may independently contribute to the risk of abortion with odds ratios (95% confidence intervals) , 0.895 (0.850-0.943), 1.123 (1.018-1.240), 26.857 (8.769-82.250) respectively, with associated p-values of