article · The Journal of Infectious Diseases

Risk Factors for Immunological Sensitization to <i>Mycobacterium tuberculosi</i> s and Progression to Incident TB Disease Among HIV-uninfected Adults in a High Burden Setting

Humphrey Mulenga
Gavin Churchyard
Michèle Tameris
Munyaradzi Musvosvi
Adam Penn-Nicholson
Kogieleum Naidoo
Andrew Fiore-Gartland
Simon C Mendelsohn
Gerhard Walzl
Thomas J Scriba
Mark Hatherill

2026Open accessStellenbosch University

Abstract

Mtb-sensitized individuals had a three-fold higher risk of prevalent TB and progressing to TB compared to Mtb-unsensitized individuals. In high-prevalence settings, identifying individuals at greatest risk-such as those recently infected, with a history of smoking, or low BMI-could help refine TB prevention efforts and reduce community-level transmission.

Research topics

Tuberculosis Research and Epidemiology
Mycobacterium research and diagnosis
Infectious Diseases and Tuberculosis

Sustainable Development Goals

Good Health and Well-being

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DOI: 10.1093/infdis/jiag100

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