review · International Journal of Biological and Chemical Sciences
Gomphrena celosioides Mart, widely known as bachelor's button, has a long history of use in traditional medicine, where all parts of the plant are employed for diverse therapies. A systematic review gathered and evaluated data on the plant's medicinal value, chemical profile, and toxicological effects from academic databases and textbooks. The analysis confirmed the presence of diverse classes of phytocompounds throughout the plant. Furthermore, synthesized evidence from laboratory and animal studies showed that plant extracts exhibit multiple pharmacological actions. These include anti-diabetic, antimicrobial, anti-inflammatory, analgesic, gastroprotective, hepatoprotective, diuretic, antihypertensive, and antioxidant activities. These scientific findings lend support to the traditional health claims associated with the species, highlighting the plant as a strong candidate for subsequent clinical investigation and targeted drug discovery.
Traditional herbal remedies frequently offer valuable starting points for modern medical treatments. By systematically collecting and confirming the biological effects of Gomphrena celosioides Mart, this review validates historical folklore with experimental data. This provides researchers and healthcare innovators with clear scientific justification to investigate the plant further for potential pharmaceutical developments.
This research presents early-stage findings relevant to pharmaceutical developers and natural product chemists seeking novel drug leads. The documented bioactivities suggest potential applications in developing treatments for infections, diabetes, inflammation, or liver conditions. However, commercial application remains at a very early, preclinical stage, as further isolation of specific active compounds and subsequent clinical experimental studies are required before therapeutic products can be developed.
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Gomphrena celosioides Mart (G. celosioides) is a promising medicinal plant commonly known as bachelor’s button. Traditionally, all the parts of G. celosioides Mart are used for different folkloric medicinal purposes. This review sought to provide a detailed update on G. celosioides Mart, with the goal of synthesizing data from different sources on its medicinal values, phytochemistry and toxicological effects. This paper also provides information on the ethnopharmacological relevance of G. celosioides and scientific experimental evidence that is useful to prioritize the plant and certain phytocompounds found in it that may be new drug leads. All relevant information regarding G. celosioides Mart were retrieved from textbooks and electronic databases (PubMed, Google Scholar, and Semantic Scholar) using the search term “Gomphrena. celosioides Mart”. Analysis revealed the identification of various classes of phytocompounds from different parts of the plant. In addition, data on extracts of G. celosioides Mart through in vivo and in vitro studies gathered on this appraisal demonstrated pharmacologic activities including anti-diabetes mellitus, anti-microbial, gastroprotective, hepatoprotective, antioxidant, diuretics, hypertension, anti-inflammatory, and analgesic, thus giving credence to its folklore. In light of the available evidence, it can be said that G. celosioides Mart is a valuable medicinal plant worthy of consideration for clinical experimental studies. Further research is needed to validate the other folklore claims and explore the bioactive compounds responsible for reported pharmacological activities in extracts.
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DOI: 10.4314/ijbcs.v19i1.25
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