review · Nutrients
Bovine colostrum, the initial milk produced by cows after giving birth, is seeing rising global consumption as a dietary supplement due to its rich concentration of bioactive substances. Beyond essential components such as immunoglobulins, oligosaccharides, lactoferrin, and lysozyme, it offers naturally high bioavailability and notable levels of growth factors. These growth factors perform vital physiological roles, including aiding wound healing, supporting muscle and bone development, and promoting growth in children. At a molecular level, they participate in cell proliferation, tissue regeneration, and immune response regulation. Synthesising evidence on growth factor concentrations, biological mechanisms, and clinical studies provides an essential foundation for determining the safe use and potential health impacts of bovine colostrum in addressing diverse bodily disorders and advancing clinical applications.
Bovine colostrum is increasingly popular as a health supplement, making it vital to understand how its active components work. Examining its potent growth factors helps explain how the substance aids tissue repair, physical development, and immune function, providing scientific backing to ensure consumers and healthcare providers can use these natural products safely and effectively.
The findings support applications in dietary supplements, clinical nutrition, and regenerative therapies aimed at wound healing, paediatric growth, and musculoskeletal support. Commercial users include supplement manufacturers and clinical nutrition developers. Because the work reviews existing clinical studies and molecular mechanisms while calling for further research into safety and specific bodily disorders, the application pathway remains in the early-to-mid clinical research stage rather than immediate new clinical deployment.
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Colostrum is a nutritious milk synthesized by mammals during the postpartum period, and its rich bioactive components has led to a global increase in the consumption of bovine colostrum as a supplement. Bovine colostrum contains key components such as immunoglobulins, oligosaccharides, lactoferrin and lysozyme. It is a special supplement source due to its natural, high bioavailability and high concentrations of growth factors. Growth factors are critical to many physiological functions, and considering its presence in the colostrum, further research must be conducted on its safe application in many bodily disorders. Growth factors contribute to wound healing, muscle and bone development, and supporting growth in children. Additionally, the molecular mechanisms have been explored, highlighting the growth factors roles in cell proliferation, tissue regeneration, and the regulation of immune responses. These findings are crucial for understanding the potential health effects of bovine colostrum, ensuring its safe use, and forming a basis for future clinical applications. This review article examines the growth factors concentration in bovine colostrum, their benefits, clinical studies, and molecular mechanisms.
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DOI: 10.3390/nu16142359
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