Relationship between antibody avidity, Fc-mediated functional activity and longevity of malaria vaccine responses in clinical trials

Abstract

Antibody avidity was not a better predictor of Fc-mediated functional activity than antibody magnitude and avidity was not a strong correlate of antibody longevity. These findings suggest that vaccine approaches that focus on increasing antibody avidity <i>per se</i> may not be sufficient to achieve more efficacious or long-lasting vaccines.