article · Food Reviews International
Propolis is a resinous substance formed by bees through the combination of botanical sources and their own secretions, long attracting interest across traditional and modern medicine. Recent scientific literature records the identification of several previously unknown chemical compounds within the material. It exhibits an extensive spectrum of biological activities, including antibacterial, antiparasitic, antiviral, antioxidant, antileishmanial, anti-inflammatory, antidiabetic, immunomodulatory, and anticancer properties. Toxicological data indicates that propolis possesses low toxicity, retaining safety even when administered in high doses. Because of its safety profile and diverse functional properties, propolis provides a viable natural reservoir of bioactive molecules that can be explored for the discovery and design of novel therapeutic drugs.
Natural products frequently provide starting points for life-saving medicines. Confirming the wide array of biological activities in propolis, alongside documented low toxicity at elevated doses, reinforces the value of bee-derived resources in healthcare. This knowledge provides scientists and healthcare sectors with evidence to explore propolis compounds for treating infectious and non-infectious conditions.
The findings are applicable to pharmaceutical companies and drug development researchers seeking natural bioactive compounds to design therapies for infections, metabolic disorders, or cancer. Given that the abstract synthesises laboratory-level chemical identifications and biological properties from literature rather than completed clinical products, the research represents an early-stage pathway to commercial drug discovery.
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Propolis is a resinous substance from beehive produced by the combination of plants and bee secretions. For a long time, this substance has gotten high attention in traditional and modern medicine. The aim of this review was to discuss the recent advances in the chemical composition and biological activities of propolis. The search for recent publications was based on several databases, such as PubMed, Google Scholar, Science-Direct, and Web of Sciences using relevant keywords. Literature data showed that several new compounds have recently been identified in propolis. The most important biological properties of propolis were discussed in this review, namely antibacterial, antiparasitic, antiviral, antioxidant, antileishmanial, anti-inflammatory, antidiabetic, immunomodulatory, and anticancer. In terms of safety, the data showed low toxicity of propolis even at high doses. Overall, propolis can be considered a promising source of bioactive compounds for drug development.
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DOI: 10.1080/87559129.2022.2089164
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